Semaglutide 0.25 mg to 2.4 mg pre-filled injection pens
Semaglutide is a GLP-1 receptor agonist given as a once-weekly injection under the skin, from a pre-filled pen. It is authorised in two separate product lines: one for blood sugar control and cardiovascular risk in adults with type 2 diabetes, and one for chronic weight management. The pens, the strengths and the dose steps differ between them. Semaglutide carries a boxed warning about thyroid tumours and is available only on a valid prescription.
This medicine is dispensed only against a valid prescription. Don’t have one? Order anyway — one of our doctors will call you for a free consultation after you order, and the medicine ships only if it is prescribed for you.
A licensed pharmacist reviews every prescription before this medicine is dispensed.
How it works- Pharmacist checked Every order reviewed
- Tracked delivery Tracked to your door
- Genuine packaging Sealed and verified
- Licensed pharmacy Prescription only
Medicine information
Semaglutide uses
Semaglutide is authorised for adults, in two distinct product lines with different pens and different maximum doses. These are the uses on the labels. Which product and which dose apply to you is your prescriber’s decision.
- To improve blood sugar control in adults with type 2 diabetes, as an addition to diet and exercise.
- To reduce the risk of major cardiovascular events — cardiovascular death, non-fatal heart attack and non-fatal stroke — in adults with type 2 diabetes and established cardiovascular disease.
- To reduce the risk of worsening kidney function, end-stage kidney disease and cardiovascular death in adults with type 2 diabetes and chronic kidney disease.
- For chronic weight management in adults with obesity, or who are overweight and have at least one weight-related condition, alongside a reduced-calorie diet and increased physical activity. This is a separate authorisation, with its own pen and its own dose steps up to 2.4 mg weekly.
Semaglutide is not authorised for type 1 diabetes. The diabetes product and the weight-management product are not interchangeable, and a pen prescribed for one is not a substitute for the other. Your prescriber may use it for other purposes; follow their instructions, not this page.
How to use semaglutide
Semaglutide is a once-weekly injection you give yourself under the skin. Your prescriber or a nurse should show you the technique before your first dose, and the pen comes with a step-by-step instructions-for-use leaflet — read it.
- Inject once a week, on the same day each week. You can change the day as long as the last dose was at least 2 days before.
- Inject at any time of day, with or without meals.
- Inject under the skin of the abdomen, thigh or upper arm. Rotate the site each week.
- Do not inject into a vein or muscle.
- The label starts everyone at 0.25 mg once weekly for 4 weeks. That starting dose is for getting used to the medicine, not for blood sugar control.
- After 4 weeks the label increases the dose to 0.5 mg once weekly, and further if needed. The maximum on the label is 2 mg once weekly. Your prescriber sets your steps and timing.
- Use a new needle for every injection, and never share a pen with anyone else even with a new needle.
- If you also take insulin or a sulfonylurea, ask your prescriber about adjusting those doses and about how to recognise and treat low blood sugar.
If you miss a dose
If you miss a dose, inject it as soon as you can within 5 days of the missed day, then go back to your usual weekly schedule. If more than 5 days have passed, skip that dose and take the next one on your normal day. Never take two doses to catch up.
Storage
Before first use, keep the pen in the fridge at 2 to 8 °C and do not freeze. After first use, the pen can be kept for 56 days (8 weeks) either in the fridge at 2 to 8 °C or at room temperature below 30 °C. Keep the cap on, remove the needle after each injection, protect the pen from light and heat, and throw it away after 56 days even if medicine is left in it.
Semaglutide side effects
Stomach side effects are common, especially in the first weeks and after each dose increase, and usually settle. Tell your prescriber if they do not, or if you cannot keep fluids down.
Common
Serious — seek urgent care
- A lump or swelling in the neck, hoarseness, difficulty swallowing or shortness of breath — report these to your prescriber promptly, as the label asks, because of the thyroid tumour warning.
- Severe, persistent abdominal pain, often spreading to the back, with or without vomiting — possible pancreatitis. Stop the medicine and seek urgent care.
- Severe or continuous vomiting or diarrhoea that leaves you unable to drink — dehydration can injure the kidneys. Seek medical advice.
- Pain in the upper right abdomen, fever, yellowing of the skin or eyes, or pale stools — possible gallbladder problems. Seek urgent care.
- Shakiness, sweating, confusion, fast heartbeat or fainting — low blood sugar, most likely if you also take insulin or a sulfonylurea. Treat it and tell your prescriber.
- Swelling of the face, lips, tongue or throat, or difficulty breathing — call emergency services.
Warnings
- Boxed warning: in rodents, semaglutide caused thyroid C-cell tumours, including medullary thyroid carcinoma. Whether it does so in humans is not known.
- Do not use semaglutide if you or a family member has had medullary thyroid carcinoma, or if you have Multiple Endocrine Neoplasia syndrome type 2.
- Do not use semaglutide if you have had a serious allergic reaction to semaglutide or any ingredient in the pen.
- Pancreatitis has been reported with GLP-1 medicines including semaglutide. Tell your prescriber if you have had pancreatitis before, and stop and seek care for severe abdominal pain.
- Tell your prescriber if you have diabetic retinopathy. More eye complications were seen with semaglutide (3.0%) than with placebo (1.8%) in the cardiovascular outcomes trial, and rapid improvement in blood sugar can temporarily worsen diabetic eye disease. Report any change in your vision to your prescriber.
- Tell your anaesthetist and surgeon that you take semaglutide before any procedure with sedation or general anaesthesia. The label warns about food remaining in the stomach and the risk of it entering the lungs.
- If you also take insulin or a sulfonylurea, your risk of low blood sugar goes up. Your prescriber may reduce those doses.
- Semaglutide is not for type 1 diabetes and is not a treatment for diabetic ketoacidosis.
- Tell your prescriber if you are pregnant, planning a pregnancy or breastfeeding. The label advises stopping semaglutide at least 2 months before a planned pregnancy because of how long it stays in the body.
- Never share a pen with another person, even if the needle is changed. Sharing risks passing on blood-borne infection.
Semaglutide FAQs
Is semaglutide approved for weight loss?
Yes, but only as a separate product. Semaglutide is authorised in one product line for blood sugar control and cardiovascular risk in adults with type 2 diabetes, and in another for chronic weight management in adults with obesity or who are overweight with a weight-related condition. They use different pens and different dose steps, and prescribing the diabetes product for weight alone is off-label. We dispense against what your prescriber writes and cannot advise you on which is appropriate for you — that conversation belongs with them.
How long does semaglutide take to work?
Blood sugar starts to change within the first weeks, but the 0.25 mg starting dose is deliberately a run-in dose, chosen so your stomach can adjust, not to control glucose. Most people move to 0.5 mg after 4 weeks and may go higher after that. The label expects the full effect of a given dose to take several weeks to show, so HbA1c is usually rechecked after about three months. Do not increase your own dose because progress feels slow — dose steps belong to your prescriber.
What happens if I miss my weekly semaglutide dose?
If it is within 5 days of the day you should have injected, take it as soon as you can and then go back to your usual weekly day. If more than 5 days have gone by, skip that dose entirely and take the next one on your normal schedule. Do not double up. If you miss doses often, tell your prescriber — restarting after a long gap sometimes means going back to a lower dose, because tolerance to the stomach side effects fades when you stop.
How do I store a semaglutide pen, and can it stay out of the fridge?
Before first use, keep the pen in the fridge at 2 to 8 °C, and never freeze it — a frozen pen must be thrown away. Once you have used it, the pen can be kept for 56 days (8 weeks) either in the fridge or at room temperature below 30 °C, with the cap on and away from light and heat. Take the needle off after each injection. After 56 days, throw the pen away even if there is medicine left. If a pen has been left somewhere hot, or has frozen, do not use it — ask our pharmacist.
Can I buy semaglutide online without a prescription?
No. Semaglutide is a prescription-only medicine and we dispense it only against a valid prescription from your licensed prescriber. It carries a boxed warning about thyroid tumours, is contraindicated in people with a personal or family history of medullary thyroid carcinoma or MEN 2, and interacts with insulin and sulfonylureas in ways that can cause dangerous low blood sugar. A licensed pharmacist reviews every order here. Semaglutide sold without a prescription, or compounded from unlicensed sources, is a route we will not touch.
What strengths and pack sizes do you dispense, and what does it cost?
We dispense semaglutide injection pens as 0.25 mg/1.5 mL (1 pen), 0.5 mg/1.5 mL (1 pen), 1 mg/3 mL (1 pen), 1.7 mg/3 mL (1 pen) and 2.4 mg/3 mL (1 pen). The current price for each pack is shown on this page and again in your cart before you pay, with no membership fee and no tiers. Stock may be branded or generic on any given day, depending on what is in supply; the active ingredient, the strength and the pack size are what the label says either way. What we dispense is set by your prescription rather than by what you select, so if the quantity on your prescription differs from the pack you picked, our pharmacist will contact you before anything is sent.
Where do you ship semaglutide, and how is the cold chain handled?
We dispense only where we are licensed to dispense, and the checkout tells you whether we can ship to your address before you pay. Semaglutide needs to stay refrigerated until first use, so it ships in insulated packaging with cooling, and delivery windows are shorter than for tablets. If a parcel arrives warm, arrives damaged, or has clearly been frozen, do not use the pen — contact us and our pharmacist will deal with it. Current timings and carriers are on our shipping page.
What is the thyroid cancer warning on semaglutide about?
In rodent studies, semaglutide caused dose-related thyroid C-cell tumours, including medullary thyroid carcinoma, at exposures relevant to human doses. Whether the same happens in people is not known — the relevance of the rodent finding to humans has not been determined. Because of that uncertainty, semaglutide carries a boxed warning and is contraindicated for anyone with a personal or family history of medullary thyroid carcinoma or with MEN 2. The label asks you to report a neck lump, hoarseness, trouble swallowing or shortness of breath to your prescriber.
- Strengths
- Solution for injection in pre-filled pens: 0.25 mg, 0.5 mg, 1 mg, 1.7 mg and 2.4 mg
- Pack sizes
Pack Price 0.25 mg/1.5 mL · 1 pen $160.65 0.5 mg/1.5 mL · 1 pen $169.15 1 mg/3 mL · 1 pen $203.15 1.7 mg/3 mL · 1 pen $237.15 2.4 mg/3 mL · 1 pen $271.15 - Form
- Injection
- Type of medicine
- GLP-1 receptor agonist
- SKU
- CD-OZE-RX
- Storage
- Before first use, keep the pen in the fridge at 2 to 8 °C and do not freeze. After first use, the pen can be kept for 56 days (8 weeks) either in the fridge at 2 to 8 °C or at room temperature below 30 °C. Keep the cap on, remove the needle after each injection, protect the pen from light and heat, and throw it away after 56 days even if medicine is left in it.
- Prescription status
- Prescription required
- Manufacturer packaging
- Sealed, batch number on the label
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This information is a summary and does not replace the patient information leaflet or your prescriber's advice. Pharmacist review pending.


























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